[written July 2022, last revised Aug 2022]
The effort to understand the universe is one of the very few things that lifts human life a little above the level of farce, and gives it some of the grace of tragedy. - Steven Weinberg
I. Questions that bother me greatly, happening to be the most unanswerable ones.
Good scientific methodology is not an abstract set of rules dictated by philosophers. It is conditioned by, and determined by, the science itself… Let's not put the cart before the horse. Science is the horse that pulls the cart of philosophy. - Leonard Susskind
The primordial question.
How did the universe begin?1
Was there even a beginning?2
The problem of gravity.
What is gravity? On large scales, it shows itself as a two-way street between spacetime curvature and energy (the central concept of general relativity), but what is it at the fundamental/quantum level?3
The trouble with quantum mechanics.
The trouble is not that Nature is probabilistic as opposed to deterministic; probabilities in themselves are not too terrible, for one at least gets precise predictions for those.4
The trouble is, as Steven Weinberg put it, why do probabilities get into quantum mechanics at all? That is the very bridge between the microscopic deterministic world of the quantum and the macroscopic world of observations. It is hence the heart of all the unease about quantum physics.5
Another way to state the problem: how do you prove the Born rule? Standing independent of the Schrodinger equation,6 it is the rule that states that the absolute square of a particle's wavefunction must be interpreted as the probability density of its presence at a given point. Nobody knows why.7
The problem of time.
What is time?
In quantum mechanics time is an absolute background quantity — unlike position, it is not an operator8 — and observer-independent. Whereas in relativity (both special and general), it's an observer-dependent malleable on the same footing as space. How are these two pictures compatible?
Why is there a directionality to time? The "arrow of time" seems to appear on two different levels. As a macroscopic phenomenon, it is equivalent to the continual increase of entropy as per the Second Law of Thermodynamics. At a fundamental level, it shows up as the violation of charge-parity symmetry in the weak interactions. Are these arrows related?
Why is there just one dimension of time?9
The cosmological constant problem: "the worst prediction in physics".
Why is the universe big? as Nima Arkani-Hamed elegantly states it. More precisely stated, why is the minimum gravitating energy density of spacetime, sourced by fluctuations of quantum fields, 122 orders of magnitude smaller than standard expectation (or 56 orders if the Standard Model is somehow the ultimate theory of quantum fields)?10 The observed value of the energy density of the vacuum is the caloric content of one little crystal of sugar per cubic kilometre — still enough to contribute to three-fourths the energy budget of the current universe. Yet the expectation is that just a cubic zeptometre (10-63 m3) should contain enough energy to unbind the Milky Way.
Spooky observation: had the measured cosmological constant been slightly larger while remaining positive, not only would the cosmological horizon be smaller than observed, but galaxies would not have formed, as the first over-densities would have been ripped apart, preventing their role as seeds for amassing neighbouring matter; had it been slightly larger and negative, the universe would have by now shrunk to a psychotically tiny volume via a Big Crunch. Both scenarios prompt Arkani-Hamed's question. The exceptionally tiny cosmological constant appears to be exceptionally fine-tuned for life, and hence observers.11
The electroweak hierarchy problem.
(a.k.a. the gauge hierarchy problem.)
Why is the weak force detectable? That is, why isn't the electroweak energy scale (100 GeV, corresponding to length scales of 10-18 metres) at its natural value of the Planck energy scale (1017 times greater) or something similarly large?12
Spooky observation: had the electroweak scale been slightly smaller or larger, per Donoghue et al. cosmologically long-lived nuclei and/or atoms would not have formed. The unspeakably tiny value of the electroweak scale appears to be unspeakably fine-tuned for life, and hence observers.13
Another statement of the problem,14 via reversal: why is gravity so much weaker than the other forces?15
The Fermi paradox/Drake equation.
Are we alone?
I do not get the Fermi paradox, not in my bones. It is not (yet) clear to me why intelligent life must be commonplace in the universe, i.e. whether the mediocrity principle can be applied to the emergence of a species like ours. This is to say that, on the basis of my reading and grasp, it seems to me that we have very little idea of the odds that inanimate molecules turn into microscopic life forms, and the odds that such forms turn into sapient, self-aware life.
Thus I understand Where is everybody? far less than the much more basic Are we alone? — any answer to which is, as Arthur C. Clarke wrote, terrifying.
The fundamental question.
Why is reality the way it is? Even if all the questions here get answered at some point by humanity with some "theory of everything", why is that the answer and not something else?16
A specific interest. Quantum mechanics is the underlying grammar with which all the literature of the natural world ("laws of physics") is written.17 But why quantum mechanics? Is this somehow related to the "The trouble with quantum mechanics" above?
Sean Carroll: "Do advances in modern physics and cosmology help us address these underlying questions, of why there is something called the universe at all, and why there are things called 'the laws of physics,' and why those laws seem to take the form of quantum mechanics, and why some particular wave function and Hamiltonian? In a word: no. I don't see how they could."
The mystery of mysteries.
Why is mathematics so unreasonably effective in describing the natural sciences?18
II. Questions of interest the answers to which are highly desirable.
Nature uses only the longest threads to weave her patterns, so each small piece of her fabric reveals the organization of the entire tapestry. - Richard Feynman
The chirality of life.
Why are live molecules left-handed? Has it do with the left-chirality of the weak interactions (whose provenance is in itself a mystery; see below) — cosmic muons selecting left-handed amino acids over lengthy times?
If so, does this lend more credence to the anthropic solution to the electroweak hierarchy problem?
The matter-antimatter imbalance.
Why do we see only matter in the visible macroscopic universe, and not antimatter? What (mechanism of baryogenesis) set off this asymmetry, which started out as one lone extra baryon for every billion baryon-antibaryon pairs? How come the universe didn't just begin with a symmetric population of matter and antimatter, which would all have annihilated away into radiation by now?19
The flavour problem: basic.
Who ordered that? - I. I. Rabi.
Why are there three near-identical copies of matter? Why didn't Nature stop at 1? If going for more, why did she stop at 3?20
The mystery of charge quantization.
Why does electric charge seem to come in units of the absolute charge of down-type quarks (1/3 e)?21
Is spacetime supersymmetric?
Is the symmetry that unites fermions and bosons realized in Nature?22
Supersymmetry is the only loophole to the Coleman-Mandula no-go theorem, which states that spacetime and internal symmetries of any theory must factorize.23 A supersymmetric extension to the Standard Model will certainly mitigate the electroweak hierarchy problem, if not provide a candidate for dark matter (in versions with "matter parity" or "R-parity") and facilitate a precise unification of the gauge forces.24
III. Questions of interest to which the want of an answer wouldn't kill me.
We live on an island surrounded by a sea of ignorance. As our island of knowledge grows, so does the shore of our ignorance. - John Wheeler
The dark matter problem.
What is the microscopic identity of dark matter,25 the invisible substance that makes up five-sixths of the mass of the matter content of the universe, and which via gravitational condensation gave the cosmos its current looks on the largest scales?
The parity problem.
Why do weak interactions act only on left-handed matter (those with left helicity, roughly)? In other words, if the universe were seen in a point mirror, the weak force vanishes like a vampire.26 Why?
The flavour problem: advanced.
Why is there a peculiar pattern of masses and mixings among fermions? And why is there a vast hierarchy of masses in each family? The {tauon, top quark, bottom quark} outweigh the {electron, up quark, down quark} by {3600, 34800, 4200}. What sets the CP-violating phase among the quarks?
And then there are neutrinos. Why are their masses ridiculously tiny? The sum of the three neutrino masses is at best a million times smaller than the electron mass.27 Are neutrinos their own anti-particles? And what sets the CP-violating phase among them?
The strong CP problem.
Why does the strong interaction seem symmetric under time-reversal (equivalent to a charge-parity transformation if Lorentz symmetry holds) while nothing prevents the violation of said symmetry?28
The character of high density matter.
What is the phase — and equation of state — of matter at densities above nuclear saturation, for instance in the inner core of neutron stars? Is it merely nucleons, or do you have matter with strange content such as hyperons and kaons, or do you have free quarks, or something a touch more exotic like a colour-flavour-locked phase?
Experimental anomalies.
Here are some deviations from the Standard Model observed in experiments, presented roughly in the order of my belief in their reality. Their possible solutions are too numerous to list here. Explanations have fallen broadly under three categories or somewhere in between: (i) there is an unknown bug in the experiment, (ii) the Standard Model prediction was not calculated right, (iii) some exotic new physics is causing the anomaly.
The muon magnetic moment.
What explains the long-standing discrepancy with the Standard Model in measurements of the anomalous magnetic moment of the muon, first observed at Brookhaven and recently again at Fermilab?
The Galactic Center excess.
Why is the central 10 degrees of the Milky Way shining excessively in gamma rays?29
The Hubble tension.
Why is the Hubble constant measured significantly smaller —at a 4.4 $\sigma$ level — in the cosmic microwave background (the early universe) than in the expansion rate from standard candles, e.g. Type Ia supernovae (the late universe)?30
The neutron lifetime puzzle.
Why do neutrons seem to disappear faster from traps than the rate at which their decay products appear from neutron beams?
The cosmological lithium problem.
Why does the abundance of lithium-7 alone fall short of the prediction of Big Bang Nucleosynthesis, when all the lighter nuclides are in spectacular agreement with BBN+CMB?
The DAMA/LIBRA anomaly.
What is causing the DAMA/LIBRA experiment to see a highly significant annually modulating signal over two decades even while other experiments with similar set-ups fail to replicate it?
The mass of the W boson.
What made CDF at Tevatron measure the W boson's mass significantly higher than everyone else?
There is a theory which states that if ever anyone discovers exactly what the Universe is for and why it is here, it will instantly disappear and be replaced by something even more bizarre and inexplicable. There is another theory which states that this has already happened. - Douglas Adams